首页>
外国专利>
NOVEL DERIVATIVES OF XANTIE, METHOD OF OBTAINING THEM, PHARMACEUTIC AGENT, APPLICATION OF SUCH DERIVATIVES IN PRODUCTION OF THE PHARMACEUTIC AGENT AND METHOD OF OBTAINING SAME
NOVEL DERIVATIVES OF XANTIE, METHOD OF OBTAINING THEM, PHARMACEUTIC AGENT, APPLICATION OF SUCH DERIVATIVES IN PRODUCTION OF THE PHARMACEUTIC AGENT AND METHOD OF OBTAINING SAME
omega -Amino-hydroxyalkynyl substituted xanthine derivatives of formula (I) are new: R1 and/or R3 = group of formula (a) or (b); and when only one of R1 and R3 is group (a) or (b) the other is H or R8; R8 = 1-6C alkyl, 3-6C cycloalkyl or 4-8C cycloalkyl-alkyl; R2 = 1-5C alkyl, 3-6C cycloalkyl or 4-8C cycloalkyl-alkyl; R4 = H or 1-3C alkyl; R5-R7 = H, 1-6C alkyl, 3-6C cycloalkyl, 4-8C cycloalkyl-alkyl, Ar-1-2C alkyl or tri(1-4C alkyl)silyl; or NR5R6 = 4-7 membered saturated ring optionally substituted by 1-4 1-4C alkyl and/or containing O, S, SO, SO2 or NR13 in place of 1 CH2; R13 = H, 1-3C alkylcarbonyl or 1-4C alkyl; A = 1-6C alkylene; Z- = inorganic or organic acid anion.
展开▼
机译：式（I）的ω-被氨基-羟基炔基取代的黄嘌呤衍生物是新的：R 1和/或R 3 ＝式（a）或（b）的基团;当R 1和R 3中只有一个为基团（a）或（b）时，另一个为H或R 8; R 8 ＝ 1-6C烷基，3-6C环烷基或4-8C环烷基-烷基; R 2 ＝ 1-5C烷基，3-6C环烷基或4-8C环烷基-烷基; R 4 ＝ H或1-3C烷基; R 5 -R 7 ＝ H，1-6碳烷基，3-6碳环烷基，4-8碳环烷基-烷基，Ar1-2C烷基或三（1-4C烷基）甲硅烷基;或NR 5 R 6 ＝ 4-7元饱和环，其任选地被1-4个1-4C烷基取代和/或含有O，S，SO，SO 2或NR 13代替1 CH 2; R 13 ＝ H，1-3C烷基羰基或1-4C烷基; A = 1-6C亚烷基; Z-＝无机或有机酸阴离子。
展开▼
