CAMPTOTHECINE ANALOGUES, METHOD FOR PREPARING THEREOF, INTERMEDIATE COMPOUNDS AND A PHARMACEUTICAL COMPOSITION CONTAINING SAID CAMPTOTHECINE ANALOGUES

摘要

A camptothecin analogue characterised in that the hydroxy lactone of the camptothecin is a -hydroxy lactone or of corresponding -hydroxyacid, resulting from the opening of said lactone, or a derivative of said -hydroxyacid, or a pharmaceutically acceptable salt thereof, is disclosed. In particular, compounds of formulae (I) and (II) are disclosed. Methods for preparing of compounds of formulae (I) and (II), pharmaceutical compositions containing said compounds, and their use, particularly as topoisomerase inhibitors and tumoral drugs, are also disclosed.