PEPTIDES RECEIVING T-CELLS AS THERAPEUTIC AGENTS FOR AUTOIMMUNITY AND MALIGNAL DISEASES.

摘要

PEPTIDES AND PHARMACEUTICAL COMPOSITIONS ARE PRESENTED THAT CONTAIN IMMUNOGENIC PEPTIDES OF A CHARACTERISTIC T-CELL RECEIVER (TCR) OF A DISEASE RELATED TO THE IMMUNE SYSTEM, ABLE TO PREVENT, DELETE OR TREAT. IN A PREFERRED ASPECT OF THE INVENTION, THE AMINO ACID SEQUENCE OF THE PEPTIDE CORRESPONDS TO AT LEAST A COMPLEMENTARY DETERMINING REGION (CDR) OR A HYPERVARIABLE TCR REGION. ANTIBODIES AND / OR IMMUNOLOGICALLY REACTIVE CELLS ARE ALSO PRESENT TO THE TCR PEPTICE ABLE TO PREVENT, SUPPRESS OR TREAT AN IMMUNE SYSTEM RELATED TO A PASSIVE TRANSFER.