A process for the preparation of phosphatidylserines.

摘要

A process for the preparation of phosphatidylserines of formula (I) wherein R1 and R2 are independently acyl saturated C10-C30 monounsaturated or polyunsaturated, x = OH or OM, wherein M = alkali or alkaline earth, ammonium, alkylammonium (including the inner salt), comprising the reaction of phosphatides of general formula (II) wherein R1, R2 and x have the meanings defined above, and R3 = CH2-CH2-NH2 or CH2-CH2-N + (CH3) 3, racemic or enantiomerically pure with serine, preferably with (L) -serine, in the presence of a phospholipase D (PLD), characterized in that the reaction medium is an aqueous dispersion and that the reaction is carried out in the presence of one or more surfactants in amounts below 0, 4 g per gram of phosphatides.