TETRAHYDRO-BENZO (D) AZEPINAS AND ITS USE AS ANTAGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS.

摘要

Compounds of the ** formula ** wherein R1 means hydrogen, C1-7 alkyl, oxygen, halogen, or -OR, -O (C3-C6) cycloalkyl, -O (CHR) n- (C3-C6) cycloalkyl, -O (CHR) nCN, -O (CHR) nCF3, -O (CHR) - (CHR) nNR2, -O (CHR) (CHR) nOR, -O (CHR) n-C2-7 alkenyl, -OCF3, -OCF2-R, -OCF2-C2-7 alkenyl, -OCHRF, -OCHF-C2-7 alkenyl, -OCF2CRF2, -OCF2Br, -O (CHR) nCF2Br, -O (CHR) n-phenyl, where the group Phenyl may optionally be substituted independently of one another by one to three C1-7 alkyl, C1-7 alkoxy, halogen, nitro or cyano groups, as well as their pharmaceutically acceptable salts in their racemic and optically active form.