DERIVATIVES OF (-) - VERBENONA.

摘要

A compound that has the formula in which: when X = 0, Z = H, = CHAr, = C (OH) COOEt, = NOR; Y = H, NH2, NH3 + X1-, NHCOAr, NHCOR, NHCONHR, NHCONHAr; X1- = pharmaceutically acceptable anion; Ar = aryl or heteroaryl, preferably phenyl, 4-chlorophenyl, 2-furyl, 2-thienyl, 2- hydroxyphenyl, 2-acetoxyphenyl; R = H, C1-C4 alkyl, C4-C6 cycloalkyl, CH2COOH, CH2COOEt, CH2COCH3, CH2CN, CH2COCH2COOEt, CH2C6H5; with the proviso that when X = 0 and Y = H, Z is different from H; and, when X = dimethylamino, diethylamino, pyrrolidino, piperidino or morpholino; Y = H; Z = H, CONHAr, CONHR; Ar = aryl, preferably phenyl; R = H, C1-C4 alkyl, C4-C6 cycloalkyl, with the proviso that when Z = H, X is different from pyrrolidino.