A method for screening for negative side effects of a sex steroid compound orcomposition in a subject, by carrying out an assay onthe subject or on a sample derived from the subject determining whether anincrease of the compound or composition on the level of anacute phase reactant or a metabolic derivative thereof has occurred sinceapplying the compound or composition to the subject, said acutephase reactant being selected from the group consisting of positive AcutePhase Reactants (APRs) with the exclusion of ceruloplasminand coagulation/thrombosis associated factors, whereby an increase in thelevel of the acute phase reactant is indicative of negative sideeffects. A sex steroid compound or composition characterised by a lowerincrease in APR level as determined in a manner according tothe invention than a third generation oral contraceptive, said compound orcomposition not being a second generation oral contraceptive.
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