SYNTHESIS AND CHARACTERIZATION OF NOVEL SYSTEMS FOR GUIDANCEAND VECTORIZATION OF COMPOUNDS HAVING A THERAPEUTIC ACTIVITY

摘要

The present invention relates to a process for the preparation of a cyclopeptide homodetic grafted forming a frame defining two faces, a so-called face upper and a so-called lower face, said two faces being all two grafts, characterized in that a linear peptide is synthesized, said synthesis being carried out from amino acids modified or not, some of them carrying orthogonal protective groups, we perform intramolecular cyclization of the linear protected peptide obtained, we substitutes all or part of the orthogonal protective groups with a precursor protected, grafted onto one and / or the other face of said chassis, by a connection oxime, at least one molecule of interest.