2-PHENYL-BENZIMIDAZOL AND 2-PHENYL-IMIDAZO-`4,5!-PYRIDINE DERIVATIVES AS CHECKPOINT KINASE CDS1 (CHK2) INHIBITORS FOR THE TREATMENT OF CANCER

摘要

2-Phenyl substituted benzimidazoles and imidazo[4,51pyridines of formula(I)are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapyor radiation therapy in the treatment of cancer. Wherein W is -COOH, -(CO)NH2,or -(SO2)NH2; Q is N or CH; Z is selected from the group consisting of a)C=O, C=CHRf, CRdRd, CF2, CRdORe, C(ORd)ORe, b) C(Rd)NRdRg, C) -SO2NRdC(Rh)2-, where A is fuse d at the b or c faces, at a face of A whichcontains two carbon atoms, which is saturated or unsaturated, where A is fusedat the b or c; faces, at a face of A which contains two carbon atoms, which issaturated or unsaturated, d) NC1-4alkyl, where the alkyl is optionallysubstituted with a. substituent selected from the group consisting of -NH2, -NHC1-4alkyl, -N(C1-4aIkyl)2, -CONH2, -CONHC1-4alkyl-, -CON(C1-4aIkyl)2, -COOH,--COOC1-4alkyl, -OH and -OC1-4alkyl; A is selected from the group consistingof: a) phenyl or other substituents defined in claim1. The other substituentsare as defined in claim1.