METHOD FOR EXAMINING AND EVALUATING VIRUS ENZYMES IN HTS

摘要

The invention relates to cell culture systems used to examine the activity of viral proteases NS2/3 and NS3/4A of the hepatitis C virus (HCV) and to identify substances in high throughput screening (HTS) which modulate the activity of the proteases. The system has a modular design and makes examination possible for cis-cleavage activity and trans-cleavage activity according to protease type and structure.