Diagnostics and therapeutics for diseases associated with human phosphodiesterase 4d (pde4d)

摘要

The invention provides a human PDE4D which is associated with the disorders of the peripheral and central nervous system, cardiovascular diseases, hematological diseases, respiratory diseases and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of disorders of the peripheral and central nervous system, cardiovascular diseases, hematological diseases, respiratory diseases and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of PDE4D as well as pharmaceutical compositions comprising such compounds.