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Gallium complexes of 3-hydroxy-4-pyrones to treat infection by intracellular prokaryotes, DNA viruses and retroviruses
Gallium complexes of 3-hydroxy-4-pyrones to treat infection by intracellular prokaryotes, DNA viruses and retroviruses
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机译:3-羟基-4-吡喃酮镓配合物可治疗细胞内原核生物,DNA病毒和逆转录病毒的感染
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摘要
Methods are provided for treating or preventing infections by obligate intracellular prokaryotes, including mycoplasma, rickettsia and chlamydia, and DNA viruses, including herpes viruses, papillomaviruses, adenoviruses and hepatitis B virus. The methods involve the administration of 3:1 complexes of 3-hydroxy-4-pyrones with gallium, e.g., gallium maltolate. Therapies incorporating gallium maltolate in combination with agents used against obligate intracellular prokaryote and DNA virus pathogens are also provided, as are multi-combination therapies designed to treat co-infection by an obligate intracellular prokaryote or DNA virus in an immunocompromised individual. These multi-combination therapies rely on the ability of gallium maltolate to complement antiviral medication regimes against both HIV and other pathogens such as herpesvirus infections, including Kaposi sarcoma, CMV retinitis and blindness, and lymphomas, in patients immunocompromised by HIV infection.
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