METAL SUBSTITUTED NON CENTROSIMMETRICAL PHTHALOCYANINE ANALOGUES, THEIR PREPARATION AND USE IN PHOTODYNAMIC THERAPY AND IN VIVO DIAGNOSTIC

摘要

Phthalocyanine analogues having an active group able to link the phthalocyanine to carriers molecules and phthalocyanine analogues as phthalocyanine-carrier conjugates showing enhanced photodynamic properties, red shifted absorption characteristic, all useful for photodynamic therapy, are described. Photosensitizers themselves or the photosensitizers-carrier conjugates are useful compounds either for treatment of various infectious diseases, the in vivo eradication of micro-organisms as well as diseases characterized by cellular hyperproliferation, in particular tumours psoriasis, actinic keratosis, atheromas, endoarterial hyperplasia and prostate hyperplasia. The above compounds can be also useful for blood and blood derivatives sterilization and as in vivo/vitro diagnostics.