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GERM LINE MUTATION IN THE PROMOTER OF E-CADHERIN AND DIAGNOSTIC METHOD FOR FIND ING A GREATER SUCEPTIBILITY TO GASTRIC CARCINOMA
GERM LINE MUTATION IN THE PROMOTER OF E-CADHERIN AND DIAGNOSTIC METHOD FOR FIND ING A GREATER SUCEPTIBILITY TO GASTRIC CARCINOMA
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机译:E-钙粘蛋白启动子中的生殖线突变和寻找对胃癌敏感性更大的诊断方法
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摘要
A diagnosis method is provided to identify a genetic polymorphism that leads to a greater predisposition to the onset of gastric carcinoma, according to which in fact is sought the presence of a possible polymorphism at the nucleotide -160 of the promoter of the E-caderine gene. The polymorphism involves the nucleotidic substitution of C (cytosine) with A (adenine) and it is sought through amplification obtained by the polymerase chain reaction, a method which allows the automatic amplification of the genic fragment to be sought. The polymerase chain technique uses two pairs of oligonucleotides A and B made up of particular base sequences of the E-caderine gene and supporting the sequence of interest in two separate reactions.
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