SELF-ASSEMBLING P53 PEPTIDES AS GENE DELIVERY VEHICLES

摘要

Novel delivery vehicles comprising peptide based domains that can self-assemble into multivalent assemblies are described. The multivalent assemblies are preferably tetrameric assemblies such as hp53tet¿. The peptide domain is preferably fused to a signal molecule such as a polycationic molecule. The vehicles are useful in delivering a wide range of agents to a cell including peptides, vaccines, cytotoxic molecules, plasmids, genes, drugs and diagnostic probes or agents.