A SUSCEPTIBILITY GENE FOR LATE-ONSET IDIOPATHIC PARKINSON'S DISEASE

摘要

Methods of diagnosis of susceptibility to Parkinson's disease; assays for agents that alter the activity of a Parkinson's disease polypeptide, (e.g., PARK8 polypeptide) or which identify PARK8 binding agents, and the agents or binding agents identified by the assays; PARK8 therapeutic agents, including the PARK8 nucleic acids, PARK8 polypeptides, or agents that alter the activity of an PARK8 polypeptides; pharmaceutical compositions comprising the PARK8 therapeutic agents; as well as methods of therapy of Parkinson' s disease are disclosed.