NOVEL SPIRO KETONE AND CARBOXYLIC ACID DERIVATIVES AS SPECIFIC INHIBITORS FOR (PO3H2) SER/(PO3H2)THR-PRO-SPECIFIC PEPTIDYL-PROLYL-CIS/TRANS-ISOMERASES

摘要

The present invention relates to a new low-molecular spiro, ketone and carboxylic acid compounds and their derivatives having an affinity for (PO3H2)Ser/(PO3H2) Thr-Pro-specific peptidyl-prolyl-cis/trans-isomerases of the parvuline family and which inhibit their enzymatic peptidyl-prolyl-cis/trans-isomerase activity, as well as pharmacologically acceptable salts and pharmaceutical compositions containing such compounds. Moreover, the invention relates to the use of the above-indicated compounds for the preparation of pharmaceutical compositions as therapeutics for the treatment of diseases characterised by disorders of the cell proliferation, such as e.g. in the case of cancer or infectious diseases.