MODULATION OF MITOSIS BY ENHANCING THE INTERACTION OF CDC24A AND CYCLINB/CDK1

摘要

The invention generally relates to compositions and methods for modulating entry into mitosis. In one aspect, the invention provides methods for treating or preventing a hyperproliferative disorder in a mammal by promoting the phosphorylation of Cdc25A or the dephosphorylation of cyclin B/Cdk1, or by enhancing the activity of at least one molecular component of the Cdc25A and cyclin B/Cdk1 regulatory interaction/feedback pathway. In another aspect, the invention provides compositions capable of promoting the pathway. The invention has a wide range of important applications including providing screens for compounds that enhance the activity of one or more of the molecular components in the pathway and providing methods for screening a patient population.