METHOD OF DETECTING AND PREVENTING ALZHEIMER’S DISEASE, PARTICULARLY AT PRODROMAL AND EARLY STAGES

摘要

A method of detecting Alzheimer's disease includes detecting a disruption or alteration in normal sub-cellular distribution of G-protein receptor kinases (GRKs), particularly GRK2 and GRK5. The disruption is caused by abnormal accumulation of soluble ß-amyloid. The prevention or suppression of the disease progression at prodromal or early stages includes correction of GRK dysfunction.