2,4-DIAMINOQUINAZOLINE, 2-AMINO-4-HYDROXYPTERIDINE AND 2,4-DIAMINOPYRIMIDINE ESTER DERIVATIVES AS DIHYDROFOLATE REDUCTASE INHIBITORS

摘要

This invention relates to novel esters of the general formula (III), which are Dihydrofolate Reductase Inhibitors; Wherein A is a heteroaromatic group, preferably selected from formula (a), formula (b), formula (c); Wherein Rl is either hydrogen or CH3; Wherein B is selected from formula (d), formula (e), formula (f), formula (g), formula (h), formula (i), formula (j): and salts thereof.