COMPOUNDS AND METHODS FOR USE IN TREATING NEOPLASIA, CANCER, HYPERPROLIFERATIVE CELL GROWTH AND CHRONIC INFLAMMATORY DISEASES

摘要

The present invention relates to a novel method for the treatment of neoplasia, including cancer and other diseases and conditions in humans and mammals. More particularly, in preferred aspects, the present invention provides a method for the use of a novel class of chemical agents, the 3H-1,2-Dithiolo[4,3-d]pyrimidin-5,7-diones and 4H-1,3-Dithiino[5,4-d]pyrimidin-8-one-7S-oxides and the respective nucleosides and nucleotides, for the treatment of both neoplasia, drug sensitive and drug-resistant breast, colon, ovarian and lung cancer, among others, hyperproliferative cell growth, chronic inflammatory diseases and viral and other microbial infections.