首页> 外国专利> DELIVERY AGENT, METHOD OF DELIVERING A TARGET SUBSTANCE TO CELLS, METHOD FOR PRODUCING DELIVERY AGENT, COMPOSITION FOR PRODUCING DELIVERY AGENT, AND KIT FOR PRODUCING DELIVERY AGENT

DELIVERY AGENT, METHOD OF DELIVERING A TARGET SUBSTANCE TO CELLS, METHOD FOR PRODUCING DELIVERY AGENT, COMPOSITION FOR PRODUCING DELIVERY AGENT, AND KIT FOR PRODUCING DELIVERY AGENT

机译:递送代理,将靶标物质递送至细胞的方法,递送代理的制备方法,递送代理的制备组合物和递送代理的试剂盒

摘要

The present invention provides a delivery agent having superior reproducibility and biocompatibility that allows a target substance to be efficiently delivered to cells. In a delivery agent comprising compound particles of DNA and a calcium phosphate-based material, the release time of DNA inside a cell can be controlled to realize efficient cell transfection by adjusting the dissolution rate of the compound particles relative to pH so that at least 50% of the compound particles present at pH 8.0 dissolve within a predetermined time after changing the pH to 6.0.
机译:本发明提供了具有优异的再现性和生物相容性的递送剂,其允许将靶物质有效地递送至细胞。在包含DNA化合物颗粒和磷酸钙基材料的传递剂中,可以通过调节化合物颗粒相对于pH的溶出度至至少50来控制细胞内DNA的释放时间,以实现有效的细胞转染。在pH值改变为6.0后的预定时间内,pH值为8.0的化合物颗粒的100%溶解。

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