This invention is a pupilometer (10) having a pupil irregularity or non-uniformity detection capability. The pupilometer may comprise an imaging sensor (14) for generating signals representative of a pupil of an eye (43), a data processor, a program executable by the data processor for enabling the data processor to process signals received from the imaging sensor, and to thereby identify one or more regions of non-uniformity within an image of a perimeter of the pupil. The pupilometer may incorporate several innovative calibration, threshold routines, which may provide the basis for an innovative medical diagnostics system, when coupled to a network containing a suitable medical database, and data processing hardware.
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