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ATTACHMENT OF BIOMOLECULE TO A POLYMERIC SOLID SUPPORT BY CYCLOADDITION OF A LINKER
ATTACHMENT OF BIOMOLECULE TO A POLYMERIC SOLID SUPPORT BY CYCLOADDITION OF A LINKER
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机译:通过连接子的循环负载将生物分子连接到聚合物固体支持物上
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摘要
The present invention provides solid supports (e.g., glass) and polymer hydrogels (particularly polymer hydrogel arrays present on a solid support) comprising one or more reactive sites for the attachment of biomolecules, as well as biomolecules comprising one or more reactive sites for attachment to solid supports and polymer hydrogels. The invention further provides novel compositions and methods for the preparation of biomolecules, solid supports and polymer hydrogels comprising reactive sites. The invention also provides for preparation of crosslinked solid supports, polymer hydrogels, and hydrogel arrays, wherein one or more biomolecules is attached by means of the reactive sites in a photocycloaddition reaction. Advantageously, according to the invention, crosslinking of the hydrogel and attachment of biomolecules can be done in a single step.
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