Caenorhabditis elegans chemosensory bioassay for seven transmembrane receptor ligands
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机译:秀丽隐杆线虫化学感应生物测定的七个跨膜受体配体
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摘要
This invention relates to methods for producing a transgenic C. elegans that expresses a human 7TMR pan-neuronally, such that said transgenic C. elegans exhibits a known phenotype. These transgenic C. elegans can be used in a variety of ways, including, but not limited to: (1) screening and identifying substances that bind to and activate particular human 7TMRs; (2) screening for substances that antagonize human 7TMR activation; (3) identifying human 7TMRs that may respond to particular substances; and (4) evaluating the specificity and efficacy of substances on human 7TMR activation.
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机译:本发明涉及生产转基因 C I>的方法。泛神经元表达人7TMR的 elegans I>,例如所说的转基因 C I>。 线虫 I>表现出已知的表型。这些转基因 C。线虫可以以多种方式使用,包括但不限于:(1)筛选和鉴定与特定人类7TMR结合并激活它们的物质; (2)筛选能拮抗人类7TMR激活的物质; (3)识别可能对特定物质有反应的人类7TMR; (4)评估物质对人类7TMR活化的特异性和功效。
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