COMPOUND LIBRARIES OF IMIDAZO1,5-APYRIDIN-3-YL DERIVATIVES AND RELATED HETEROBICYCLES FOR TARGETTING COMPOUNDS CAPABLE OF BINDING TO G-PROTEIN COUPLED RECEPTORS

摘要

The present invention provides a library designed to take advantage of a common recognition feature of G-protein coupled receptors, namely the ‘benzhydryl’ or ‘rabbit ears’ arrangement of aromatic rings. In addition the library utilises several themes common in GPCRs selecting for subsets which recognise basic and ‘acidic’ ligands. The library comprises or consists of a set of structurally related compounds of general formulae (A)or (B). The present invention also provides intermediates (formula (3)).