1,2,4-TRIAZIN-3-YL-HYDRAZINE OR 5H-1,2,4-TRIAZINO’5,6-B!INDOL-3-YL-HYDRAZINE COMPOUNDS AS INHIBITORS OF BACE USEFUL IN THE TREATMENT OF ALZHEIMER

摘要

A compound of formula (I) wherein R1 is aryl and R2 is hydrogen; or R1 and R2 taken together form a group of formula (i) wherein R6 is alkyl or -alkyl-aryl; and R7 is hydrogen, halogen, alkyl, alkoxy or aryl; R3 is aryl, heteroaryl or -aryl-aryl; R4 is hydrogen, hydroxy or alkyl; and R5 is hydrogen or alkyl; or a pharmaceutically acceptable salt thereof, is new, for use in therapy, e.g. of Alzheimer's disease.