PROCESS FOR PREPARING AMINO COMPOUNDS BY USING SALEN-MANGANESE COMPLEXES AS THE CATALYST

摘要

Disclosed is a process for the enantioselective production of an optically active amino compound by the amination of the C-H bond of an organic compound. The amino compound is produced by converting the C-H bond at the allyl position of an alkene or the C-H bond at the benzyl position of an alkylarene to the corresponding C-N bond, using a salen-manganese complex as the catalyst and N-substituted iminoaryliodinane as the amination agent. Both the catalytic activity and the enantioselectivity are very high when there is used a catalyst in which the 3- and 5- positions of the salicylaldehyde moiety of the salen ligand are substituted with an electron-withdrawing group, particularly with a halogen atom.