COMPLEXES OF GD +3 GADOLINIUM IONS WITH DERIVATIVES OF N-2- (2- (PHENYLAMINO) -2- OXOETHYL) -N- (CARBOXYMETHYL) - GLYCINE AND METHOD FOR OBTAINING THESE COMPLEXES

摘要

Method for obtaining new complexes of Gd+3 gadolinium ions with derivatives of 2,2'-(2­(R1, R2, R3, R4, R5-phenyl)amine)-2-oxoethyl))diacetic acid of the formula (I), in which R1, R2, R3, R4 and R5 are the same or different and stand for an atom of hydrogen or an atom of halogen or an aliphatic group or an aromatic group or a nitro group or a phosphonic group or a phosphate group or a heterocyclic system including an atom of oxygen or an atom of nitrogen or an atom of sulphur, characterized in that hexahydrous gadolinium chloride is exposed to reaction with lithium salt of derivatives of 2,2'-(2-(R1, R2, R3, R4, R5-phenyl)amine)-2-oxoethyl)) diacetic acid in the medium of aliphatic alcohol, aliphatic amine, aromatic amine, dimethylsulfoxide (DMSO), dimethylformemide (DMF) at the temperature 60 °C, providing that the mole ratio of the reagents is 1:2, and next the obtained lithium salt of gadolinium complex is transformed into sodium salt which is purified by a known method. The new compounds can be applied as contrast media for non-invasive diagnostic technique, in medical imaging as for instance nuclear resonance for interior organs particularly liver.