CONJUGATES OF 2,4-ETHANO-BRIDGED AND 2,4-PROPANO-BRIDGED 3,6,9-TRIAZA-NONANOIC ACID, 3N,6N,9,9N-TETRAETHANOIC ACID, AND CORRESPONDING PHOSPHORIC ACID METHYLENE DERIVATIVES AND THE SUBSTITUTION PRODUCTS THEREOF WITH BIOMOLECULES, METHODS FOR THE PRODUCTION THEREOF, AND THE USE OF THE SAME FOR PRODU

摘要

The invention relates to conjugates of 2,4-ethano-bridged and 2,4-propano-bridged 3,6,9-triaza-nonanoic acid, N,N,N-tetraethanoic acid, and corresponding phosphoric acid ester methylene derivatives of formula (1) - wherein the substituents are defined as cited in patent claim 1 - and the substitution products thereof with biomolecules. The invention also relates to methods for producing said conjugates and to the use of the same as contrasting media in NMR diagnosis and radiodiagnosis, and for radiotherapy.