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Recombinant fowlpox virus with intact FPV-tk-gene
Recombinant fowlpox virus with intact FPV-tk-gene
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机译:具有完整FPV-tk基因的重组鸡痘病毒
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摘要
A process for producing a recombinant protein is described according to which vertebrate host cells or cell cultures are infected with a recombinant virus comprising a plasmid which comprises at least the FPV tk-gene, a downstream intergenic region and the following 3' open reading frame (3' orf) of fowlpox virus (FPV), wherein said intergenic region is modified to form an enlarged intergenic region which comprises one or more unique restriction sites thereby allowing insertion of foreign DNA in such a way that the FPV tk-gene remains intact and codes for the entire thymidine kinase (TK) and said recombinant virus comprises DNA coding for said protein.
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