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AN IN VIVO ANIMAL MODEL OF CHRONIC ARTERIAL OCCLUSION AND USE OF COLLAGENASE TO FACILITATE GUIDE WIRE CROSSING IN CHRONIC ARTERIAL OCCLUSIONS
AN IN VIVO ANIMAL MODEL OF CHRONIC ARTERIAL OCCLUSION AND USE OF COLLAGENASE TO FACILITATE GUIDE WIRE CROSSING IN CHRONIC ARTERIAL OCCLUSIONS
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机译:慢性动脉闭塞的体内动物模型和胶原酶的使用有助于慢性动脉闭塞的指导线交叉
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摘要
The use of a collagenase containing formulation for degrading collagen within an occlusive atherosclerotic plaque in a chronic fibrotic occlusion, chronically occluded animal tube or cavity. A medical-related apparatus is provided comprising a medical-related device having provided thereto a therapeutic amount of a collagen degrading composition comprising a proteiolytic enzyme containing formulation A method is provided for treating chronically occluded animal tubes and cavities by administering a therapeutic effective amount of a proteolytic enzyme-containing formulation adjacent to an occluding atherosclerotic plaque, waiting for a pre-angioplasty waiting period, followed by crossing the plaque with an angioplasty guide wire.
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