USE OF SELECTIN-BINDING ACTIVE INGREDIENTS FOR THE TREATMENT OF INFLAMMATORY AND TUMORAL DISEASES

摘要

A selectin-binding active agents in the form of gestation proteins or fragments thereof, of liposomes which include Ca-binding compounds, of mucin fragments obtained or derived from native sources, or of mimicry compounds which imitate sialylated Lewis type carbohydrate structures (sLe), or combinations thereof, in the treatment and prophylaxis of diseases, in the course of which inflammatory processes are involved, such as autoimmune diseases, transplantations and arteriosclerosis. Inflammatory diseases in the meaning of the invention can be those of infectious or non-infectious nature. The active agents provide partial or complete prevention of tumor metastasizing, wherein administration of the active agents can be prophylactic, or can be effected in association with e.g. operative removal of a primary tumor or during a biopsy. The above active agents are used in the prophylaxis of tumor diseases.