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NOVEL DEATH ASSOCIATED PROTEINS OF THE THAP FAMILY AND RELATED PAR4 PATHWAYS INVOLVED IN APOPTOSIS CONTROL
NOVEL DEATH ASSOCIATED PROTEINS OF THE THAP FAMILY AND RELATED PAR4 PATHWAYS INVOLVED IN APOPTOSIS CONTROL
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机译:凋亡控制中涉及的THAP家族的新死亡相关蛋白和相关的PAR4途径
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摘要
The invention relates to genes and proteins of the THAP (THanatos (death)-Associated Protein) family comprising a THAP domain, and their use in diagnostics, treatment of disease, and in the identification of molecules for the treatment of disease. The invention also relates to the Par4 protein and SLC chemokine pathways, including the interaction of Par4 and SLC with THAP family proteins, and the recruitment and localization of Par4 to PML nuclear bodies.
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