A COMPOSITION FOR DELIVERING A LIPIDIZED IMMUNOGLOBULIN TO AN INTRACELLULAR COMPARTMENT OF A CELL A LIPIDIZED PROTEIN AND A LIPIDIZED ANTIBODY

摘要

The present invention provides methods for targeting proteins such as antibodies to intracellular compartments in eukaryotic cells, enhancing organ uptake of proteins, pharmaceutical compositions of modified proteins for use in human therapy, and methods for preparing modified proteins. It is about. Modified proteins of the invention include bound lipid proteins, wherein one or more acyl groups are bound to the protein through various covalent binding chemistry provided with the carbohydrate side chain. Lipidized antibodies of the invention can be used for diagnostic and therapeutic purposes.