Asymmetric Synthesis of (-) 6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one

摘要

The present invention describes an improved method for the synthesis of a highly potent HIV reverse transcription inhibitor of formula (I), involving acetylide and trifluoromethyl ketone to produce a chiral product in the presence of a chiral amino alcohol.;[Formula I]