An anticancer drug comprising a mycolactone, an antisense Rb oligonucleotide that decreases human retinoblastoma protein expression and an anticancer drug comprising a mycolactone and the said antisense Rb oligonucleotide

摘要

This invention relates to an anticancer agent comprising mycolactone, which induces apoptotic death of cancer cells and also relates to inhibitors of Rb protein expression, including an antisense Rb oligonucleotide, which sensitize cancer cells to mycolactone. This invention relates further to an anticancer agent comprising both mycolactone and the inhibitors of Rb protein expression. Mycolactone induces cell death in cancers of breast, bladder, skin, stomach, liver, colon, and oral cavity, lymphoma, and leukemia via apoptosis pathway.