Complex of Hepatitis B Virus Polymerase with p11 and Method for controlling Movement of the Complex in HepG2 Cell

摘要

PURPOSE: A complex of hepatitis B virus polymerase(HBVpol) and protein p11 and a method for controlling movement of the complex in HepG2 cell are provided, thereby detecting a position of the complex in human liver cell and disclosing the carcinogenesis mechanism of liver cancer. CONSTITUTION: A complex of hepatitis B virus polymerase(HBVpol) and a calcium binding protein p11 by noncovalently binding moves to promyelocytic leukemia nuclear body(PMLNB). A method for controlling movement of the complex in HepG2 cell comprises adding a calcium ion concentration regulating agent to the HepG2 cell to increase or decrease the calcium ion concentration in the HepG2 cell.