Membrane potential changing agent for Alysia neuron comprising hydrogen peroxide and composition for inducing Alysia neuronal death comprising the same

摘要

PURPOSE: A membrane potential changer of an aplysia neuron containing hydrogen peroxide and a cell death-inducing composition of the aplysia neuron containing the membrane potential changer are provided. Use of the composition induces a change in membrane potential and cell death of the aplysia neuron and thus can provide a model useful for the study of memory and learning. CONSTITUTION: The membrane potential changer of an aplysia neuron contains hydrogen peroxide in the range concentration of 0.01 to 10mM. The cell death-inducing composition of the aplysia neuron contains the membrane potential changer of the aplysia neuron. A change in membrane potential is hyperpolarized in the early time after hydrogen peroxide treatment and then depolarized after then. The aplysia is an Aplysia kurodai captured in a costal area of The East Sea of Korea.