Isolated anticonvulsant material from the root of Angelica dahurica Benth. et Hook.

摘要

PURPOSE: Provided is an anticonvulsant material isolated from the root of Angelica dahurica Benth. et Hook to inhibit the activity of GABA-T. It is used for a therapeutic agent for seizures, convulsions, epilepsy and the like. CONSTITUTION: An anticonvulsant material is isolated from the extract of the root of Angelica dahurica Benth. et Hook, and inhibits the activity of GABA-T. The extract is obtained by using ethylacetate, n-butanol and water, and the anticonvulsant material is imperatorine and/or falcarindiol. A pharmaceutical composition for treatment of seizures, convulsions, epilepsy and the like contains the anticonvulsant material as an active ingredient.