COOLANT COATING COMPOSITION FOR SUBSTRATES CONTAINING COATING AGENT, HEAT-STABLE HIGH-INTENSITY SWEETENER SUCH AS SUCRALOSE AND NON-VOLATILE COOLING AGENT HAVING EFFECTS OF PROVIDING COOLING SENSATION WITHOUT SUBSTANTIALLY ANY OLFACTORY STIMULATION AND DOSAGE FORMULATION IN EASY-TO-SWALLOW FORM

摘要

PURPOSE: A coolant coating composition for substrates such as those comprised of pharmaceutical active agents containing a coating agent, a heat-stable high-intensity sweetener such as sucralose and a non-volatile cooling agent is provided. It provides a cooling sensation without substantially any olfactory stimulation and a dosage formulation in easy-to-swallow form. CONSTITUTION: The coolant coating composition comprises: about 65 to 85% by weight of a coating agent; about 0.01 to 89% by weight of a heat-stable high-intensity sweetener such as sucralose; 0.01 to 92% by weight of a non-volatile cooling agent having an average molecular weight of about 300amu(atomic molecular units) and additionally about 0 to about 37% by weight of a cooling auxiliary agent. The composition is selected from the group consisting of carbohydrate, a film-forming polymer, fat having a melting point of about 80deg.C, wax having a melting point of about 80deg.C and a mixture thereof. The non-volatile cooling agent is selected from the group consisting of methyl ester carboxamide, urea, phosphine oxide and a mixture thereof.