PROTEIN MSEC7 WITH NOVEL FUNCTION USEFUL FOR STUDIES ON SYNAPTIC PLASTICITY AND GENE TRANSFER

摘要

PURPOSE: Protein msec7 with novel function is provided, which regulates neuritogenesis and synaptic transmission in neuron of Aplysia kurodai, and relates to membrane traffic of the neuron cell and modulation of actin cytoskeleton. Therefore, the protein msec7 is useful in the study on synaptic plasticity and gene transfer. CONSTITUTION: The protein msec7 regulates neuritogenesis and synaptic transmission by GEF(GDP/GTP exchange factor) activity dependent method, wherein the protein msec7 induces neuritogenesis by modulation of actin cytoskeleton; the protein msec7 increases varicosity by GEF(GDP/GTP exchange factor) activity dependent method; the protein msec7 comprises msec7-1 and msec7-2; and the protein msec7-1 is encoded by the nucleotide sequence of SEQ ID NO:1 or SEQ ID NO2, and the protein msec7-2 is encoded by the nucleotide sequence of SEQ ID NO:3.