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SPECIFIC EMULSION INCLUDING CASTOR OIL AND POLYSORBATE 80, WHICH IS USEFUL FOR TOPICAL APPLICATION AND EFFECTIVE IN TREATMENT OF LACRIMAL GLANDS AND IMPROVES ABSORPTION OF CYCLOSPORIN TO LACRIMAL GLANDS
SPECIFIC EMULSION INCLUDING CASTOR OIL AND POLYSORBATE 80, WHICH IS USEFUL FOR TOPICAL APPLICATION AND EFFECTIVE IN TREATMENT OF LACRIMAL GLANDS AND IMPROVES ABSORPTION OF CYCLOSPORIN TO LACRIMAL GLANDS
PURPOSE: A specific emulsion including castor oil and Polysorbate 80 low in the risk of irritation of occular tissue is provided. The emulsion is useful for topical application and effective for treatment of lacrimal glands and improves absorption of cyclosporin to lacrimal glands. CONSTITUTION: The non-irritating eye drops contain: 0.625% or more by weight of castor oil; 0.1% or more by weight of Polysorbate 80; 0.05% by weight of acryate/C10-30 alkyl acrylate cross-polymers containing cyclosporin A ; 2.2% by weight of glyceride; water; additionally 1.0% by weight of Tween 80 and 2.20% by weight of glycerine. The weight ratio of castor and Polysorbate 80 is 0.3 to 30. The weight ratio of cyclosporin A and castor oil is 0.12 to 0.02.
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