New 2-(1-((hetero)aryl(oxy))-ethyl)-nitrobenzene derivatives, useful for introducing intramolecular triplet sensitized photolabile protecting groups into synthons for light-controlled biopolymer production

摘要

2-(1-((Hetero)aryl or (hetero)aryloxy)-ethyl)-nitrobenzene derivatives (I) are new. Also new are nucleotide synthon compounds (II) containing a photolabile protecting group derived from (I). Nitrobenzene derivatives of formula (I) are new. R1 = halo, CN or NO2; or alkyl, alkenyl, alkynyl, alkoxy, alkoxycarbonyl, aryl, aryloxy, heteroaryl or heteroaryloxy (all optionally substituted, aryl or heteroaryl moieties being mono- or polycyclic); or adjacent groups R1 may together form a 5- or 6-membered ring (optionally containing heteroatoms); R2 = mono- or polycyclic aryloxy or heteroaryloxy; or polycyclic aryl or heteroaryl containing at least 3 fused rings; R3 = trialkylsilyl; or alkyl, alkenyl, alkynyl, alkoxy, alkoxycarbonyl, aryl, aryloxy, heteroaryl or heteroaryloxy (all optionally substituted, aryl or heteroaryl moieties being mono- or polycyclic); m = 0-4; p = 0 or 1; X = -C(O)-, -O-C(O)-, -O-C(S)- or -S(O)2-; and Y = H, leaving group or substrate. An Independent claim is included for new protected synthons (II) for the production of biopolymers, where (II) contain at least one photolabile protective group obtained by reaction of the parent synthon with (I) to cause substitution of Y.