Pharmaceutical preparation comprising α-lipoic acid, ambroxol and / or inhibitors of the angiotensin converting enzyme (ACE) and their use for the treatment of neurodegenerative diseases

摘要

The present invention relates to the use of a medicament combination for the prevention and therapy of neurodegenerative diseases (e.g. ischemic and hemorrhagic stroke, focal and global ischemia, amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, Hunntington's disease, multiple sclerosis). The active ingredient combination is at least two of the following substances: alpha-lipoic acid; Ambroxol and one or more angiotensin converting enzyme (ACE) inhibitor (s). It was surprisingly found in the experiments on which the invention is based that neuronal cells which are particularly sensitive to degenerative insults have fewer free constitutional thiol groups than is the case for other cells of the central nervous system (CNS). It was demonstrated that this reduced content of free thiol groups is causally related to the damage to these cells after a degenerative event. By using the combination of alpha-lipoic acid, ambroxol and / or an ACE inhibitor, the damage after neurodegenerative insult could be reduced by 40 to 45%.