New quaternary ammonioalkyl carbonate esters useful for treating bacterial and fungal infections and potentially useful for regulating cholesterol biosynthesis

摘要

Quaternary ammonioalkyl carbonate esters (I) are new. Quaternary ammonioalkyl carbonate esters of formula (I) are new. A = a fused ring system, a 3-7C spirostane or CHR(CH2)m, all optionally substituted with 1-12C alkyl; R = alkyl; m = 5-24; n = 1-3; R1 = H or Me; R2, R3, R4 = 1-12C alkyl; 3-8C cycloalkyl, 3-12C alkenyl, 4-8C cycloalkenyl, 3-12C alkynyl, aryl(1-4C)alkyl, (1-4C alkoxy)methyl, hydroxyethyl, hydroxypropyl or propargyl, or NR3R4 is an N-containing heterocycle or an N-containing aromatic immonium group; Y = bromide, iodide, chloride or tosylate. An Independent claim is also included for a process for preparing (I).