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Cosmetic or dermatological preparations containing oligo-peptides to lighten the skin of age spots, or to prevent skin tanning, in particular skin tanning caused by UV radiation
Cosmetic or dermatological preparations containing oligo-peptides to lighten the skin of age spots, or to prevent skin tanning, in particular skin tanning caused by UV radiation
Cosmetic or pharmaceutical compositions comprise one or more monomeric- or homo- or hetero- dimeric-, trimeric- or tetrameric- oligopeptides where the oligopeptides are based upon the sequence Val-Val-Arg-Pro. Cosmetic or pharmaceutical compositions comprise one or more monomeric- or homo- or hetero- dimeric-, trimeric- or tetrameric- oligopeptides where the oligopeptides: (a) are based upon monomers of formula (I) in which a Val may be replaced by Gly, Leu, Ile, Ser, Thr, Met or especially Ala; or (b) are based upon monomers of formula H2N-R-Val-Val-Arg-Pro-R'-COOH (II); or (c) have a molecular weight of 0.5-100 kDa and are based upon single or repeated units of (I) or (II); or (d) are acylated at the N-terminal and are of formula R1-C(=O)-NH-R-Val-Val-Arg-Pro-R'-COOH (III); or (e) are amidated at the C-terminus and are of formula H2N-R-Val-Val-Arg-Pro-R'-C(=O)N(R2)2 (IV); (f) are amidated at the C-terminus and acylated at the N-terminus and are of formula R-C(=O)-NH-R-Val-Val-Arg-Pro-R'-C(=O)-N(R2)2 (V); or (g) are of formula (II)-(V), containing 1-25 Val-Val-Arg-Pro units and where R = a bond or an amino acid sequence with up to 5 amino acid units and R' = an amino acid sequence of up to 15 amino acid units. R, R' = amino acid sequences of 0-5 amino acid units; R1 = hydrocarbon group (especially 1-30C alkyl); R2 = H or R1. An Independent claim is included for use of the above oligopeptides for treatment of unwanted skin-pigmentation.
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