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combinations of lamivudine and entecavir for treatment of hepatitis b virus infection
combinations of lamivudine and entecavir for treatment of hepatitis b virus infection
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机译:拉米夫定和恩替卡韦联合治疗乙型肝炎病毒感染
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摘要
The present invention relates to therapeutic combinations comprising (2R,cis)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-pyrimidin-2-one (lamivudine) and BMS-200475 which have anti-hepatitis B virus (HBV) activity. The present invention is also concerned with pharmaceutical compositions containing said combinations and their use in the treatment of HBV infections including infections with HBV mutants bearing resistance to nucleoside and/or non-nucleoside inhibitors.
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