MEDICINES FOR THE TOPICAL USE OF SEXUAL HORMONES FOR TREATING THE DRY EYE, AND METHOD FOR THE PRODUCTION AND USE THEREOF

摘要

A topical drug application for the alleviation of keratoconjunctivitis sicca (dry eye syndrome) is comprised of a solution of sex steroids or their derivatives suspended or dissolved in a vehicle, and the method of preparation and application of the same. In the preferred embodiments, the sex steroid consists essentially of conjugated estrogen in a lipid vehicle or a derivative of estrogen known as 17 beta-Estradiol 3-phosphate disodium dissolved in an aqueous vehicle having a pH of between 6 and 8.