EGF-like factor of chromaffin granules and neurotrophic factor derived from glial cells with survival-promoting activity on dopaminergic neurons

摘要

The present invention relates to chromaffin granule-derived EGF-like proteins that are involved in promoting survival of DAergic neurons, to nucleotide sequences encoding said proteins or a functionally active derivative or part thereof, and to processes for their preparation. The present invention relates further on to glia cell-derived neurotrophic factors that are capable of promoting survival of DAergic neurons, to nucleotide sequences encoding said factors or a functionally active derivative or part thereof, and to a process for their preparation.